PRMT1 CLIA Kit for Human(Homo sapiens) | EIAab.comPRMT1 CLIA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > PRMT1(Gene name) > Human

PRMT1 (Gene name),

Protein arginine N-methyltransferase 1 (Protein name ), ANM1_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

PRMT1(HMT2;HRMT1L2;IR1B4);

Protein name:

Protein arginine N-methyltransferase 1;

Alternative:

Interferon receptor 1-bound protein 4;2.1.1.125;Histone-arginine N-methyltransferase PRMT1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer and heterodimer with PRMT8. The dimer can then associate to form a homohexamer. Interacts with ILF3, BTG1, BTG2, SUPT5H and interferon-alpha/beta receptor 1. Interacts with NFATC2IP.

Function:

Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway.

Subcellular Location:

Nucleus Cytoplasm cytosol

Protein Attributes:

Sequence length:

361

Sequence:

50:

100:

150:

200:

250:

300:

350:

361:

ELSCSTDYRM | R

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

Pfam:

PF13847

SMR:

Q99873

UniGene:

Hs.20521

Pfam:

PF06325

String:

Q99873

KEGG:

hsa:3276

MIM:

602950

Uniprot:

Q99873

FOR

ELISA Kit for Human Protein arginine N-methyltransferase 1

Cat.:

E15261h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human Protein arginine N-methyltransferase 1

Cat.:

E15261r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human Protein arginine N-methyltransferase 1

Cat.:

E15261m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Protein arginine N-methyltransferase 1

Cat.:

U15261r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Protein arginine N-methyltransferase 1

Cat.:

U15261m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Protein arginine N-methyltransferase 1

Cat.:

U15261h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human Protein arginine N-methyltransferase 1

Cat.:

P15261Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Protein arginine N-methyltransferase 1

Cat.:

P15261Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Protein arginine N-methyltransferase 1

Cat.:

P15261Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Protein arginine N-methyltransferase 1

Protein for Human Protein arginine N-methyltransferase 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2)."
Scott H.S. , Antonarakis S.E. , Lalioti M.D. , Rossier C. , Silver P.A. , Henry M.F.
Genomics48:330-340(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];ALTERNATIVE SPLICING
2.

"Structural and functional conservation of human and yeast HCP1 genes which can suppress the growth defect of the Saccharomyces cerevisiae ire15 mutant."
Nikawa J. , Nakano H. , Ohi N.
Gene171:107-111(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Glial cell.
3.

"Genomic organization, physical mapping, and expression analysis of the human protein arginine methyltransferase 1 gene."
Scorilas A. , Black M.H. , Talieri M. , Diamandis E.P.
Biochem. Biophys. Res. Commun.278:349-359(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING;TISSUE SPECIFICITY
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
tissue: Uterus.
5.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
6.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4)
tissue: Lung.
9.

"Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3."
Tang J. , Kao P.N. , Herschman H.R.
J. Biol. Chem.275:19866-19876(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ILF3
10.

"The structure and oligomerization of the yeast arginine methyltransferase, Hmt1."
Weiss V.H. , McBride A.E. , Soriano M.A. , Filman D.J. , Silver P.A. , Hogle J.M.
Nat. Struct. Biol.7:1165-1171(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
11.

"Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1."
Strahl B.D. , Briggs S.D. , Brame C.J. , Caldwell J.A. , Koh S.S. , Ma H. , Cook R.G. , Shabanowitz J. , Hunt D.F. , Stallcup M.R. , Allis C.D.
Curr. Biol.11:996-1000(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN METHYLATION OF HISTONE H4;CATALYTIC ACTIVITY
12.

"Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor."
Wang H. , Huang Z.-Q. , Xia L. , Feng Q. , Erdjument-Bromage H. , Strahl B.D. , Briggs S.D. , Allis C.D. , Wong J. , Tempst P. , Zhang Y.
Science293:853-857(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN METHYLATION OF HISTONE H4;CATALYTIC ACTIVITY
13.

"Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties."
Kwak Y.T. , Guo J. , Prajapati S. , Park K.-J. , Surabhi R.M. , Miller B. , Gehrig P. , Gaynor R.B.
Mol. Cell11:1055-1066(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SUPT5H
14.

"Regulation of estrogen rapid signaling through arginine methylation by PRMT1."
Le Romancer M. , Treilleux I. , Leconte N. , Robin-Lespinasse Y. , Sentis S. , Bouchekioua-Bouzaghou K. , Goddard S. , Gobert-Gosse S. , Corbo L.
Mol. Cell31:212-221(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt."
Yamagata K. , Daitoku H. , Takahashi Y. , Namiki K. , Hisatake K. , Kako K. , Mukai H. , Kasuya Y. , Fukamizu A.
Mol. Cell32:221-231(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FOXO1;MUTAGENESIS OF VAL-82; LEU-83 AND ASP-84
16.

"PRMT1 and Btg2 regulates neurite outgrowth of Neuro2a cells."
Miyata S. , Mori Y. , Tohyama M.
Neurosci. Lett.445:162-165(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
17.

"Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state."
Pahlich S. , Zakaryan R.P. , Gehring H.
Proteins72:1125-1137(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EWS AND PRMT8
18.

"Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4."
Lakowski T.M. , Frankel A.
Biochem. J.421:253-261(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES
19.

"PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function."
Jobert L. , Argentini M. , Tora L.
Exp. Cell Res.315:1273-1286(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
20.

"PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling."
Weber S. , Maass F. , Schuemann M. , Krause E. , Suske G. , Bauer U.M.
Genes Dev.23:118-132(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
21.

"Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells."
Chang Y.I. , Hua W.K. , Yao C.L. , Hwang S.M. , Hung Y.C. , Kuan C.J. , Leou J.S. , Lin W.J.
J. Biol. Chem.285:20595-20606(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
22.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

Product Feedback Wall

* Email:
*Comments: